Why Is Tetradentate Coordination Essential for Potential Copper Homeostasis Regulators in Alzheimer's Disease?
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چکیده
منابع مشابه
Interaction of the copper chaperone HAH1 with the Wilson disease protein is essential for copper homeostasis.
The delivery of copper to specific sites within the cell is mediated by distinct intracellular carrier proteins termed copper chaperones. Previous studies in Saccharomyces cerevisiae suggested that the human copper chaperone HAH1 may play a role in copper trafficking to the secretory pathway of the cell. In this current study, HAH1 was detected in lysates from multiple human cell lines and tiss...
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The accumulation of redox-active metal ions, in particular copper, in amyloid plaques is considered to the cause of the intensive oxidation damage to the brain of patients with Alzheimers disease (AD). Drug candidates based on a bis(8-aminoquinoline) tetradentate ligand are able to efficiently extract Cu(2+) from copper-loaded amyloids (Cu-Aβ). Contrarily, in the presence of a bidentate hydroxy...
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ژورنال
عنوان ژورنال: European Journal of Inorganic Chemistry
سال: 2019
ISSN: 1434-1948
DOI: 10.1002/ejic.201900951